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Santorini Conference

2016

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Santorini Conference

2018

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Ansari Marc (Geneva, Switzerland)
Auffray Charles (Lyon, France)
Barouki Robert (Paris, France)
Bühlmann Roland P. (Schönenbuch, Switzerland)
Dedoussis George (Athens, Greece)
Deloukas Panos (Cambridge, United Kingdom)
Fitzgerald Peter (Crumlin, Co Antrim, UK)
Froguel Philippe (Lille, france)
Ingelman-Sundberg Magnus (Stockholm, Sweden)
Jacobs Peter (Gent, Belgium)
Lamont John (Co-Antrim, United Kingdom)
Llerena Adrian (Badajoz, Spain)
Lindpaintner Klaus (Waltham, USA)
März Winfried (Mannheim, Germany)
Manolopoulos Vangelis G. (Alexandroupolis, Greece)
Meier-Abt Peter (Basel, Switzerland)
Meyer Urs A. (Basel, Switzerland)
Noyer-Weidner Mario (Berlin, Germany)
Roses Allen (Durham, US)
Siest Gérard (Nancy, France) †
Siest Sofia (Nancy, France)
Van Schaik Ron (Rotterdam, Netherlands)

UMR INSERM U1122; IGE-PCV

Interactions Gène-Environnement en Physiopathologie Cardio-Vasculaire, Nancy, France

Siest Sofia
Siest Gérard †
Hiegel Brigitte
Vermion Catherine
Stathopoulou Maria
Petrelis Alexandros
Masson Christine
Chatelin Jérôme
Arguiñano Alex-Ander Aldasoro
Xie Ting
Klein Marc
Rancier Marc
Weryha Georges Richard

Com&Co, Marseille
Etienne Jarry

Chair: Georges Weryha, France

Members:
Andriana Kaliora, Greece,
Mario Noyer-Weidner, Germany
Tomris Ozben, Turkey
Ingolf Cascorbi, Germany,
Maria Stathopoulou, France
Alexandros Petrelis, France

Scientific Topics The Santorini Conferences are bringing together scientists from various origin interested in genetics and biological variations in man and its impact on the origin, prediction, prevention, diagnosis and therapy of human multifactorial disorders. The first event, held in 2002, was opened by Jean Dausset’s notes on predictive medicine and a lecture by Klaus Lindpaintner on the “Impact of Genetics and Genomics on Health Care”.

The second conference, in 2004, had Doug Wallace’s opening lecture on “Mitochondrial DNA Diversity in Health and Disease” as one of its notable highlights. The third conference, held in 2006, focused on the identification of novel molecular biomarkers as enabled by “Omics” approaches. Conferences in 2008, 2010, 2012 and 2014 were oriented around the concept of systems biology and applications to personalized health and therapy (be it pharmaceutical or nutritional).

The integration of Omics with genetics hold great potential to better understand the complex interplay between static genetic pre-disposition and dynamic environmental effects (e.g. nutritional, infections, xenobiotics) and the consequences for health maintenance, disease development and personalized therapy. Although progress has been made in our understanding of population variation and associated risk factors, in complex diseases, such as cancer, atherosclerosis, diabetes and brain disorders, their understanding remains the biggest challenge. Inflammation is often one of the major players. However changes in lifestyle and other environmental conditions, combined with genetic predisposition, appear to underlie the most recent epidemics of chronic disease and may hold the key to influencing the trends in their incidence and management. In addition, infectious diseases particularly viral ones represent an important aspect of environment influence. Technological advancements have been profuse and must be considered as the foundation of current and future progress. Modern sequencing platforms, microarrays, high-throughput SNP detection technologies, gene transcript profiling, quantitative multiplexed proteomics, metabolomics analysis and cellular models are indispensable tools driving the rapid progress in personalized treatment and intervention.

The organization of an ever increasing information load is becoming as important as generating the underlying raw data. Establishing and managing databases and further improving the tools to retrieve, visualize, validate, interpret and cross-correlate the data are therefore becoming essential components in this scenario. Modelisation is necessary. It will be important and necessary to develop new specific softwares for predicting risk and interpreting the large amount of data. All these aspects are linked in the systems biology/systems medicine approach.

One of the greatest obstacles remaining is the setting up, funding and monitoring of large prospective, population-based cohort studies, comprising possibly several hundred thousand individuals, from whom DNA, plasma and cells will have to be collected and established in biobanks associated with high quality clinical data, GWAs are then possible. Upgrading diagnostic laboratories to incorporate these new technologies is already taking place. However, despite tremendous scientific efforts, as represented by the unprecedented speed with which new data are being generated, surprisingly little molecular research has so far been successfully translated into clinical practice. This deceiving finding has several reasons: (i) Data do not equal information: the translation of the raw measurements into interpretable and actionable read-out is challenging; (ii) Omics can deliver biomarker and target candidates without pre-conception; however, these candidates need to be validated and managed within research pipelines; (iii) the acceptance of the new holistic concepts by health care professionals represents one of the major hurdles impeding the use of available pharmacogenetic/nutrigenetic/- genomic knowledge in reaching better informed treatment decisions.

Thus, it appears important not only to foster translational research but also to enable concurrent development and implementation of the necessary educational tools. The latter should ensure that molecular and personalized medicine/treatment is taught well and systematically applied in today’s health care systems. Whilst most would agree that this transition will take time, there is, however, no time to lose. On the basis of this introduction, our objectives, both general and specific, for the 2016 conference are outlined below: Bridging Omics And Genetics in a system biology approach To study the networks of interacting genes, proteins and biochemical reactions in physiological states or variable illnesses, particularly cardiovascular diseases, Alzheimer, infections and cancer).

To analyse the functional significance of gene polymorphisms and protein isoforms by studying gene and protein networks, and to link them to health maintenance, diseases predisposition or personalized therapy. To increase the knowledge of the interplay between genetic disposition, environment including infection (viral, bacterial, parasitological), nutritional factors and drug intake. To compare the results obtained by genome wide association studies with the case-control ones. To address the use of blood cells as a source of information and their exploitation as “sentinels” in the above contexts. To communicate state-of-the-art information on molecular markers for multifactorial diseases, pharmacogenomics and personalised medicine. To evaluate the comparison of diagnostic approach To assess the suitability of these markers for the prediction of physiological deviations such as obesity, of other disease risks and of drug response, including adverse side effects, at individual or population level.

To describe emerging laboratory tools for molecular analysis and their combination with imaging technologies for comprehensive health assessment including aging and monitoring of therapeutical intervention.

  • Behrooz Z. Alizadeh, Gröningen, The Netherlands
  • Marc Ansari, Geneva, Switzerland
  • Robert Barouki, Paris, France
  • Laurent Becquemont, Paris, France
  • Lynn Bekris, Cleveland, US
  • Roland P. Bühlmann, Basel, Switzerland
  • Ingolf Cascorbi, Kiel, Germany
  • Blandine Comte, Saint Genes Champanelle, France
  • Georges Dagher, Paris, France
  • Georges Dedoussis, Athens, Greece
  • Panos Deloukas, London, United Kingdom
  • Pierre Yves Dietrich, Geneva , Switzerland
  • Robin Everts, San Diego, USA
  • Pilar Francino, Valencia, Spain
  • Philippe Froguel, Lille, France
  • Amalia Gastaldelli, Pisa, Italy
  • Steffen Gay, Zurich, Switzerland
  • Olivier Herault, Tours, France
  • Magnus Ingelmann Sundberg, Stockholm, Sweden
  • Federico Innocenti, Chapel Hill, NC, USA
  • Andriana Kaliora, Athens, Greece
  • Maja Krajinovic, Montreal, Canada
  • Alexander Kryukov, Moscow, Russia
  • Adrian Llerena, Badajoz, Spain
  • Klaus Lindpaintner, Waltham, USA
  • Janja Marc, Ljubljana, Slovenia
  • Michael Marschler, Mannheim, Germany
  • Winfried März, L, Augsburg, Germany
  • Milica Medic-Stojanoska, Oxford, UK
  • Peter Meier-Abt, Bern, Switzerland
  • Urs Meyer, Basel, Switzerland
  • Pierre Mutzenhardt, Nancy, France
  • Tiago Nava, Montreal, Canada
  • Gonzalo H Oporto V, Temuco, Chile
  • Tomris Ozben, Antalya, Turkey
  • Andreas Papassotiropoulos, Basel, Switzerland
  • Aurore Perrot, Nancy , France
  • Munir Pirmohamed, Liverpool, United Kingdom
  • Allen D. Roses, Chapel Hill, USA
  • John Ryals, Raleigh, USA
  • Giovanni Scapagnini, Molise, Italy
  • Sofia Siest, Nancy, France
  • Maurizio Simmaco, Roma, Italy
  • Ellen Umlauf, Vienna, Austria
  • Ron H. Van Schaik, Rotterdam, The Netherlands
  • Pablo Villoslada, Barcelona, Spain
  • Jean Baptiste Vincendet, Paris, France
  • Szilard Voros, Atlanta, United States
  • Erich Wanker, Berlin, Germany
  • Georges Weryha, Nancy, France
  • Jin-San Yoo, Doejean, South Korea
  • Faiez Zannad, Nancy, France

In April 9th, the entire world of laboratory medicine lost a dominating figure, a pioneer, and an innovator in the field. Gérard Siest passed away just before his 80th birthday in an unexpected and unpredictable manner.

Prof. Siest was Emeritus Professor of molecular biology and biochemical pharmacology at the Faculty of Pharmaceutical Sciences and former director of the postgraduate course in Biochemical Pharmacology at the University Henri Poincaré in Nancy (currently “Université de Lorraine”), France. During his brilliant academic carrier, he became the founder and head of the clinical laboratory and research group of the “Centre de Médecine Preventive” in Nancy for 37 years (1968-2005) and the Director of a research lab at the Faculty of Pharmacy called “Centre du Médicament”.

As an extremely hardworking person Prof. Gérard Siest was well known to the scientific community as author of more than 800 publications in peer reviewed journals and his work was honored by 27 awards from sixteen different countries. He was strongly involved in activities of many International and European professional societies. He served as President of IFCC (1991-1996). Since 2011, he was dedicated to the foundation of the European Society of Pharmacogenomics and Personalised Therapy (ESPT), which under his inspired leadership has gained worldwide visibility and is currently an important scientific stakeholder in the field of pharmacogenomics and personalised medicine. After organizing for many years the “Pont à Mousson – Biologie Prospective” international meetings, he was dedicated to the continuous organization of the ‘Santorini conferences’ on personalized medicine, which he founded in 2002.

His editorial activities encompass a range of important appointments, such as Editor-in-Chief of Clinical Chemistry and Laboratory Medicine (1998-2008), Editor-in-Chief of Drug Metabolism and Personalized Medicine (2010-2015), and member of the Editorial Boards of many other European and international journals.

He also received numerous international prices and awards.

Only once, every one or two generations, a brilliant mind emerges with all the talent, vision and personal characteristics capable of influencing entire fields of science. Gérard Siest was just one of these people. Gérard was called “the man with eternal smile” − to highlight a trait of his character − so dynamic, full of energies, but always open for discussions and sharing visions and projects with many other scientists.

Gérard’s sudden death leaves a huge gap in the scientific community. We have lost a unique clever and talented Colleague and Mentor, an exceptional and innovative scientist, a pleasant friend and a full of life and energy beloved husband.

We will miss Gérard, his tireless enthusiasm, his determination, his visionary leadership and friendship, but we will always honor his memory by assuring the continuity of his work. It’s the reason why the “Santorini Conference” 2016 will run and we will do our best to make it a success with all of you.

Sofia Siest & all the INSERM U1122 Unit team “Gene-Environment Interactions in Cardio-Vascular Physiopathology” (IGE-PCV)

Welcome Letter

A suffering took place this year on our Life’s path. It came and stays deep inside our heart. The suffering for a very significant person… Gérard SIEST passed away just one month before his 80th birthday and he never received his Birthday gift: 8 Poppies…

Day after day the poppies invited me to enjoy reading a small book of Rosette Poletti called “La voie du coquelicot”, “The poppy’s path”. I found there some sentences, which accompany me and that I wanted to share with you on the first day of this conference, October 3rd, the Name Day of Gerard…

I quote: “To continue on the path of the poppy is like walking and taking the step forward…  It’s by walking that the path can be created…”

In line with this, twenty years ago, Gerard SIEST visited Santorini for the first time. I can’t say that I remember much or that it enchanted him. I remember a magical view of the caldera and a unique, breathless, extremely serene and dreamy smile on Gérard’s face while losing his gaze on the horizon. The island had bewitched him! It became his small paradise…

And in 2002, the story begins…

 The “1st Santorini Conference “From Genetic Variations to Risk Prediction and Pharmacogenomics” was organised on 25-28 September 2002!

In some outstanding cases, inspiration confirms the talent and resulting work speaks for itself. And Gerard SIEST was one of those cases, whose ideas have taken the “Santorini Conferences” by storm.

Throughout the 14 years, 8 “Santorini Conferences” welcomed each time, about 150 registered participants coming from more than 30 different countries, 50 invited speakers and 20 selected oral presentations, 50 posters and exhibitions to a world of passion for science with specific Personalised Medicine sessions on Genetics and Pharmacogenomics of risks and chronic diseases.

From innovative projects, such as the creation of the European Society of Pharmacogenomics and Personalised Therapy (ESPT) in 2010 and upcoming research to the quintessence of personalised medicine with “hidden” and famous researchers, the “Santorini Conferences” had many faces and like a chameleon had the capacity to enchant academic and industry research in many ways.

Over the years, the “Santorini Conferences” became one of the most important conferences on genetic predisposition to health, disease, response to drugs and environment, in harmony with the island creative spirit, attracting scientists from all over the planet. None can dispute the unique vision of Gerard!

After 14 years, we are here again to follow the path along the caldera of the 8th Santorini Conference “Systems medicine and Personalised Health and Therapy” that Gerard had already initiated before passing away. The time has come to honour the memory of Gerard and our scientific guests and sponsors!

You will never get bored of this conference, that’s for sure!

Sofia SIEST,
President of the 8th Santorini Conference

Steering Committee (SC)

  • Sofia Siest, Nancy, France (President)
  • John Lamont, Crumlin, County Antrim, United Kingdom
  • Michael Marschler, Mannheim, Germany
  • Robert Barouki, Paris, France
  • Athanase Benetos, Nancy, France
  • Georges Dagher, Paris, France
  • Panagiotis Deloukas, London, United Kingdom

Scientific Advisory Board (SAB)

  • Sofia Siest, Nancy, France (President)
  • John Lamont, Crumlin, County, United Kingdom
  • Michael Marschler, Mannheim, Germany
  • Robert Barouki, Paris, France
  • Athanase Benetos, Nancy, France
  • Georges Dagher, Paris, France
  • Panagiotis Deloukas, London, United Kingdom
  • Urs Meyer, Basel, Switzerland
  • Charity Nofziger, Salzburg, Austria
  • Markus Paulmichl, Salzburg, Austria
  • Lynn Webster, Salt Lake City, United States

UMR INSERM U1122; IGE-PCV

Interactions Gène-Environnement en Physiopathologie Cardio-Vasculaire, Nancy, France

Sofia Siest (President)
Hiegel Brigitte
Stathopoulou Maria
Petrelis Alexandros
Masson Christine
Gorenjak Vesna
Weryha Georges Richard

Com&Co, Marseille
Etienne Jarry

Chair:
Dr Maria Stathopoulou, Nancy, France

Members:
Dr Charity Nofziger, Salzburg, Austria
Dr Lynn Webster, Salt Lake City, United States

Aschard Hugues, Paris, France
Aviv Abraham, New Jersey, USA
Barouki Robert, Paris, France
Becker Karl Friedrich, Munich, Germany
Boerwinkle Eric, Houston, USA
Campbell Peter, Hinxton, UK
Caulfield Mark, London, UK
Chen Rong, Mount Sinaï, USA
Daidone Maria G., Milan, Italy
Dedoussis Georges, Athens, Greece
Deloukas Panagiotis, London, UK
Diamandis Elefterios, Toronto, Ontario, Canada
Elens Laure, Brussels,Belgium
Garrido Manuel Rosa, Los Angeles, USA
Hemingway Harry, London, UK
Innocenti Federico, Chapel Hill, USA
Makris Konstantinos, Athens, Greece
Martin Granado Noelia , Madrid, Spain
Meyer Urs A., Basel, Switzerland
Newgard Christopher B., Durham, USA
Nofziger Charity, Salzburg, Austria
Oelmueller Uwe, Hilden, Germany
Pare Guillaume, Hamilton, Ontario, Canada
Paulmichl Markus, Salzburg, Austria
Purchase Andrew, Swansea, UK
Siest Sofia, Nancy, France
Spoto Giuseppe, Catania, IT
Trembath Richard, London, UK
Webster Lynn, Salt Lake City, USA

Dear Colleagues, Dear Friends,

Throughout the past 16 years, 8 “Santorini Conferences” welcomed each time, about 140 registered participants coming from more than 30 different countries to a world of passion for science with specific Personalised Medicine sessions on Genetics and Pharmacogenomics of chronic diseases.

From innovative projects, such as the creation of the European Society of Pharmacogenomics and Personalised Therapy (ESPT) in 2010 and upcoming research to the quintessence of Personalised Medicine with promising and famous researchers, the “Santorini Conferences” had many faces and like a chameleon had the capacity to enchant academic and industry research in many ways. Over the years, the “Santorini Conferences” became one of the most important conferences on genetic predisposition to health, disease, response to drugs and environment, in harmony with the island’s creative spirit, attracting scientists from all over the planet.

After 16 years, we are here again to follow The 9th Santorini Conference “Systems medicine and Personalised Health and Therapy”: The Odyssey from Hope to Practice, with special focus on cardio-metabolic diseases and cancer.

We have conceived the idea of presenting the biggest achievements of the Personalised Medicine through time by using the trip of Odysseus from Troy to Ithaca (Odyssey, Homer) as a metaphor. In this conference, inspired from Odyssey, we attempt to embark you on a ship and take you on a journey from Troy to Ithaca, through the history of the biggest events and achievements that have paved the way to the Personalised Medicine. We will sail among important genetic discoveries, passing through projects that contributed to the progress of pharmacogenomics studies and will propose ways to overcome the obstacles that are slowing down the possibilities of the full implementation of accumulated knowledge into everyday practice. This trip aims to push back the frontiers of present knowledge of genetics and of practical use of this knowledge in preventive, diagnostic and pharmacogenomics approaches promoting a direct impact on the socio-economic aspects of public health.

We have thus designed this Conference with 9 sessions, 7 oral communications, 2 satellite meetings organised in collaboration with the VEGF Consortium and the MAST4HEALTH EU Project, 2 workshops and 62 posters (http://santoriniconference.org/).

This time, more than 150 registered participants coming from Academy, Industry and Clinics join the Conference!!!

Thank you for following the trip with us…

Sofia SIEST,
President of the Santorini Conference series