Publications

Gorenjak V, Vance DR, Petrelis AM, Stathopoulou MG, Dadé S, El Shamieh S, Murray H, Masson C, Lamont J, Fitzgerald P, Visvikis-Siest S. Peripheral blood mononuclear cells extracts VEGF protein levels and VEGFmRNA: Associations with inflammatory molecules in a healthy population. PLoS One. 2019 Aug 16;14(8):e0220902. doi: 10.1371/journal.pone.0220902

Azimi-Nezhad M, Mirhafez SR, Stathopoulou MG, Murray H, Ndiaye NC, Bahrami A, Varasteh A, Avan A, Bonnefond A, Rancier M, Mehrad-Majd H, Herbeth B, Lamont J, Fitzgerald P, Ferns GA, Visvikis-Siest S, Ghayour-Mobarhan MT. The Relationship Between Vascular Endothelial Growth Factor Cis- and Trans-Acting Genetic Variants and Metabolic Syndrome. Am J Med Sci. 2018 Jun;355(6):559-565. doi: 10.1016/j.amjms.2018.03.009.

Stathopoulou MG, Xie T, Ruggiero D, Chatelin J, Rancier M, Weryha G, Kurth MJ, Aldasoro Arguinano AA, Gorenjak V, Petrelis AM, Dagher G, Dedoussis G, Deloukas P, Lamont J, Marc J, Simmaco M, Van Schaik RHN, Innocenti F, Merlin J-L, Schneider J, Alizadeh BZ, Ciullo M, Seshadri S, Visvikis-Siest S – The VEGF Consortium. A transnational collaborative network dedicated to the study and applications of the Vascular Endothelial Growth Factor–A in medical practice: The VEGF Consortium. Clin Chem Lab Med 2018 Mar 28;56(4):83-86. doi: 10.1371/journal.pone.0220902.

Choi SH*, Ruggiero D*, Sorice R*, Song C, Nutile T, Vernon Smith A, Concas MP, Traglia M, Barbieri C, Ndiaye NC, Stathopoulou MG, Lagou V, Maestrale GB, Sala C, Debette S, Kovacs P, Lind L, Lamont J, Fitzgerald P, Tönjes A, Gudnason V, Toniolo D, Pirastu M, Bellenguez C, Vasan RS, Ingelsson E, Leutenegger AL, Johnson AD, DeStefano AL, Visvikis-Siest S, Seshadri S**, Ciullo M**. Six Novel Loci Associated with Circulating VEGF Levels Identified by a Meta-analysis of Genome-Wide Association Studies. PLoS Genet. 2016 Feb 24;12(2):e1005874. doi: 10.1371/journal.pgen.1005874.

Mazidi M, Rezaie P, Pascal Kengne A, Stathopoulou MG, Azimi-Nezhad M, Siest S. VEGF, the underlying factor for metabolic syndrome; fact or fiction? Diabetes Metab Syndr. 2016 (In press).

Rancier M*, Zaaber I*, Stathopoulou MG, Chatelin J, Saleh A, Marmouch H, El Shamieh S, Masson C, Murray H, Lamont J, Fitzgerald P, Mahjoub S, Said K, Tensaout BB, Mestiri S, Visvikis-Siest S. Pro- and anti-angiogenic VEGF mRNAs in autoimmune thyroid diseases. Autoimmunity. 2016 Sep;49(6):366-372.

Zaaber I*, Rancier M*, Stathopoulou MG, Saleh A, Marmouch H, Masson C, Murray H, Kurth MJ, Lamont J, Fitzgerald P, Mahjoub S, Said K, Bel Hadj Jrad Tensaout B, Mestiri S, Visvikis-Siest S. Plasma VEGF-related polymorphisms are implied in autoimmune thyroid diseases. Autoimmunity. 2016 Jun;49(4):229-35.

Saleh A*, Stathopoulou MG*, Dadé S, Ndiaye NC, Azimi-Nezhad M, Murray H, Masson C, Lamont J, Fitzgerald P, Visvikis-Siest S. Angiogenesis related genes NOS3, CD14, MMP3 and IL4R are associated to VEGF gene expression and circulating levels in healthy adults. BMC Med Genet. 2015 Oct 5;16:90.

Azimi-Nezhad M*, Stathopoulou MG*, Bonnefond A, Rancier M, Saleh A, Lamont J, Fitzgerald P, Ndiaye NC, Visvikis-Siest S. Associations of vascular endothelial growth factor (VEGF) with adhesion and inflammation molecules in a healthy population. Cytokine. 2013 Feb; 61(2): 602-7.

Stathopoulou MG*, Bonnefond A*, Ndiaye NC*, Azimi-Nezhad M, El Shamieh S, Saleh A, Rancier M, Siest G, Lamont J, Fitzgerald P, Visvikis-Siest S. A common variant highly associated with plasma VEGFA levels also contributes to the variation of both LDL-C and HDL-C. J Lipid Res. 2013 Feb; 54(2): 535-41.

Bonnefond A, Saulnier PJ*, Stathopoulou MG*, Grarup N*, Ndiaye NC*, Roussel R, Nezhad MA, Dechaume A, Lantieri O, Hercberg S, Lauritzen T, Balkau B, El-Sayed Moustafa JS, Hansen T, Pedersen O, Froguel P, Charpentier G, Marre M, Hadjadj S, Visvikis-Siest S. What is the contribution of two genetic variants regulating VEGF levels to type 2 diabetes risk and to microvascular complications? PLoS One. 2013;8(2): e55921.

Debette S*, Visvikis-Siest S*, Chen MH, Ndiaye NC, Song C, Destefano A, Safa R, Azimi Nezhad M, Sawyer D, Marteau JB, Xanthakis V, Siest G, Sullivan L, Pfister M, Smith H, Choi SH, Lamont J, Lind L, Yang Q, Fitzgerald P, Ingelsson E, Vasan RS, Seshadri S.Identification of cis- and trans-acting genetic variants explaining up to half the variation in circulating vascular endothelial growth factor levels. Circ Res. 2011 Aug 19;109(5):554-63. doi: 10.1161/CIRCRESAHA.111.243790.

Azimi-Nezhad M, Lambert D, Ottone C, Perrin C, Chapel C, Gaillard G, Pfister M, Masson C, Tabone E, Betsou F, Meyronet D, Ungeheuer MN, Siest SV. Influence of pre-analytical variables on VEGF gene expression and circulating protein concentrations. Biopreserv Biobank. 2012 Oct;10(5):454-61

Berrahmoune H, Lamont JV, Herbeth B, Lambert D, Masson C, McPhillips M, Fitzgerald PS, Visvikis-Siest S. Association between EGF and lipid concentrations: a benefit role in the atherosclerotic process? Clin Chim Acta. 2009 Apr;402(1-2):196-8.

Berrahmoune H, Herbeth B, Lamont JV, Masson C, Fitzgerald PS, Visvikis-Siest S. Heritability for plasma VEGF concentration in the Stanislas family study. Ann Hum Genet. 2007 Jan; 71(Pt 1): 54-63.

Berrahmoune H, Lamont JV, Herbeth B, FitzGerald PS, Visvikis-Siest S. Biological determinants of and reference values for plasma interleukin-8, monocyte chemoattractant protein-1, epidermal growth factor, and vascular endothelial growth factor: Results from the STANISLAS cohort. Clin Chem. 2006 Mar;52(3):504-10. *equal first authors **equal last authors

Kaess BM, Preis SR, Beiser A, Sawyer DB, Chen TC, Seshadri S, Vasan RS. Circulating vascular endothelial growth factor and the risk of cardiovascular events. Heart. 2016 Dec 1;102(23):1898-1901.Pikula A, Beiser AS, Chen TC, Preis SR, Vorgias D, DeCarli C, Au R, Kelly-Hayes M, Kase CS, Wolf PA, Vasan RS, Seshadri S. Serum brain-derived neurotrophic factor and vascular endothelial growth factor levels are associated with risk of stroke and vascular brain injury: Framingham Study. Stroke. 2013 Oct;44(10):2768-75

Corsi MM, Licastro F, Porcellini E, Dogliotti G, Galliera E, Lamont JL, Innocenzi PJ, Fitzgerald SP. Reduced plasma levels of P-selectin and L-selectin in a pilot study from Alzheimer disease: relationship with neuro-degeneration. Biogerontology. 2011 Oct;12(5):451-4.

Siervo M, Ruggiero D, Sorice R, Nutile T, Aversano M, Iafusco M, Vetrano F, Wells JC, Stephan BC, Ciullo M. Body mass index is directly associated with biomarkers of angiogenesis and inflammation in children and adolescents. Nutrition. 2012 Mar;28(3):262-6.

Ruggiero D, Dalmasso C, Nutile T, Sorice R, Dionisi L, Aversano M, Bröet P, Leutenegger AL, Bourgain C, Ciullo M. Genetics of VEGF serum variation in human isolated populations of cilento: importance of VEGF polymorphisms. PLoS One. 2011 Feb 9;6(2):e16982.

Ellison TS, Atkinson SJ, Steri V, Kirkup BM, Preedy ME, Johnson RT, Ruhrberg C, Edwards DR, Schneider JG, Weilbaecher K, Robinson SD. Suppression of β3-integrin in mice triggers a neuropilin-1-dependent change in focal adhesion remodelling that can be targeted to block pathological angiogenesis. Dis Model Mech. 2015 Sep;8(9):1105-19.Schiekofer S, Belisle K, Galasso G, Schneider JG, Boehm BO, Burster T, Schmitz G, Walsh K. Angiogenic-regulatory network revealed by molecular profiling heart tissue following Akt1 induction in endothelial cells. Angiogenesis. 2008;11(3):289-99.

Gallet P, Phulpin B, Merlin JL, Leroux A, Bravetti P, Mecellem H, Tran N, Dolivet G. Long-term alterations of cytokines and growth factors expression in irradiated tissues and relation with histological severity scoring. PLoS One. 2011;6(12):e29399.

Jouan-Hureaux V, Boura C, Merlin JL, Faivre B. Modulation of endothelial cell network formation in vitro by molecular signaling of head and neck squamous cell carcinoma (HNSCC) exposed to cetuximab. Microvasc Res. 2012 Mar;83(2):131-7.

Jouan-Hureaux V, Boura C, Merlin JL, Faivre B. Modulation of endothelial cell network formation in vitro by molecular signaling of head and neck squamous cell carcinoma (HNSCC) exposed to cetuximab. Microvasc Res. 2012 Mar;83(2):131-7.

En Partie financé par le Programme Opérationnel FEDER FSE Lorraine et Massif des Vosges 2014-2020.

GORENJAK V, VANCE D.R, DADE S, STATHOPOULOU MG, DOHERTY L, XIE T, MURRAY H, MASSON C, LAMONT J, FITZGERALD P, VISVIKIS-SIEST S: Epigenome-wide association study in healthy individuals identifies significant associations with DNA methylation and PBMCs extracts VEGF-A concentration Clinical Epigenetics. 2020, 12(1):79.

Patents

Brevet US 9447469B2 “Identification of Genetic Variants” (Inventor: John Lamont Randox) – 2016
Brevet WO 2014006231A1: “Association of Vascular Endothelial Growth Factor Genetic Variant with Metabolic Syndrome” (Inventor:Sophie VISVIKIS-SIEST) – 2014

UNION EUROPÉENE
Fond Européen de Développement