The STANISLAS Cohort – The STANISLAS Family Study (SFS)

Publications describing the cohort:

1. Visvikis-Siest S, Siest G. The STANISLAS Cohort: a 10-year follow-up of supposed healthy families. Gene-environment interactions, reference values and evaluation of biomarkers in prevention of cardiovascular diseases. Clin Chem Lab Med. 2008; 46(6):733–47.
2. Siest G, Visvikis S, Herbeth B, Gueguen R, Vincent-Viry M, Sass C, Beaud B, Lecomte E, Steinmetz J, Locuty J, Chevrier P. Objectives, design and recruitment of a familial and longitudinal cohort for studying gene-environment interactions in the field of cardiovascular risk: the Stanislas cohort. Clin Chem Lab Med. 1998 Jan;36(1):35-42.

Description:
Community-based population recruited in 1993-1995 (baseline, T0): 1006 families, supposed healthy and free from any declared acute and/or chronic disease. Inclusion criteria – Parents and grandparents of French origin – Residence in the Lorraine region (north-east of France) – Nuclear families comprising two parents and at least two biological children over 6 years old. Exclusion criteria – Chronic or acute disorders – Previous personal history of cardiovascular diseases. Data collected during medical visits every 5-years.

Types of tissue available:

• • EDTA plasma samples stored at -80°C
  • Extracted DNA stored at -80°C
  • Buffy coat stored at -80°C – PAXGENE blood and mRNA stored at -80°C
  • EDTA isolated Peripheral blood mononuclear cells (PBMCs) and corresponding mRNA stored at -80°C
  • Sodium heparinate isolated PBMCs extracts stored at -80°C